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§ Private Profile · Carmel, IN, USA
Sudo Biosciences is a technology company.
Sudo Biosciences develops first- and best-in-class medicines for serious neurological and immunological conditions like multiple sclerosis (MS) and other immune-mediated inflammatory conditions.
Sudo Biosciences has raised $191.0M across 4 funding rounds.
Sudo Biosciences has raised $191.0M in total across 4 funding rounds.
Sudo Biosciences is a clinical-stage biopharmaceutical company developing first- and best-in-class TYK2 pseudokinase inhibitors to treat serious neurological and immune-mediated inflammatory conditions, such as multiple sclerosis (MS), psoriasis, psoriatic arthritis, lupus, and autoimmune disorders.[1][2][4][5] The company targets the tyrosine kinase 2 (TYK2) pseudokinase domain, a key mediator in cytokine signaling pathways linked to these diseases, with a pipeline including brain-penetrant candidates for neuroinflammation and topical options for dermatologic conditions.[1][2][4] It serves patients with high unmet needs in immunology and neurology, solving problems of inadequate efficacy and selectivity in existing therapies through precision drug design.[2][3]
Founded in 2020 and backed by a $37M Series A from Frazier Life Sciences, Sudo demonstrates strong early momentum as a clinical-stage biotech with Phase 1 programs like SUDO-550 and SUDO-286 for autoimmune diseases, plus preclinical assets like SUDO-643 for nervous system disorders.[4][5][7] Headquartered in Carmel, Indiana, with operations in Menlo Park, CA, Indianapolis, IN, and London, UK, the company leverages advanced medicinal chemistry, translational biology, and patient-centered development to advance its pipeline rapidly.[2][4][6]
Sudo Biosciences was founded in 2020, emerging from discussions at Frazier Life Sciences involving a team of experienced researchers, including James A. Bristol, Ph.D., and senior advisors who identified the TYK2 pseudokinase domain as a high-potential target for next-generation therapeutics.[4] The idea stemmed from decades of scientific progress in cytokine signaling and human genetic data linking TYK2 inhibition to benefits in psoriasis, lupus, and broader autoimmune conditions like MS and ulcerative colitis.[1][2][4]
Early traction came via the $37M Series A financing led by Frazier, enabling rapid pipeline advancement to clinical stages.[4] Leadership includes CEO Scott Byrd and a global team with deep expertise in small molecule drug discovery for neurological and immunological diseases, fostering a collaborative culture focused on groundbreaking research.[2][3][6] Pivotal moments include building a differentiated pipeline supported by proteomics, biomarkers, and integrated expertise, positioning Sudo for transformative impact.[2][7]
Sudo Biosciences rides the wave of precision immunology and neuroinflammation therapeutics, capitalizing on validated TYK2 biology from human genetics and prior approvals in psoriasis/lupus to expand into underserved areas like MS and autoimmune disorders.[1][2][4] Timing is ideal amid rising demand for selective kinase inhibitors, as cytokine pathway modulation proves effective across immunology (e.g., ulcerative colitis, Crohn's) and neurology, driven by market forces like aging populations, neuroinflammatory disease prevalence, and biotech funding for differentiated assets.[4][7]
The company influences the ecosystem by pioneering next-generation TYK2 drugs, potentially setting standards for brain-penetrant and topical modalities, while its Frazier backing amplifies network effects in biopharma dealmaking and IPO/M&A pathways.[4] As a clinical-stage player, Sudo contributes to the shift toward biomarker-driven, genetically validated targets in a post-pandemic focus on chronic immune diseases.[2][5]
Sudo Biosciences is poised to advance its Phase 1 TYK2 inhibitors toward pivotal trials, with potential readouts driving partnerships or further funding in 2026–2027.[5][7] Key trends like AI-accelerated drug design, expanded TYK2 indications (e.g., IBD, ankylosing spondylitis), and neuroimmunology convergence will shape its path, amplifying influence through first-in-class approvals.[1][4] Expect evolution from pipeline builder to potential acquirer target, transforming care in immune-mediated diseases as in its origin from Frazier's vision—delivering precision medicines where patients need them most.[2][4]
Sudo Biosciences has raised $191.0M across 4 funding rounds. Most recently, it raised $30.0M Series B in February 2024.
| Date | Round | Lead Investors | Other Investors | Status |
|---|---|---|---|---|
| Feb 1, 2024 | $30M Series B | — | 5AM Ventures, Access Biotechnology, Adjuvant Capital, Andreessen Horowitz, Frazier Healthcare Partners, Brendan Bulik Sullivan, Pureos Bioventures, Sanofi Ventures, Versant Ventures, Vincent Brichard, Jonathan Behr, Juergen Eckhardt, Matthias Kleinz | Announced |
| Dec 1, 2023 | $120M Series B | — | 5AM Ventures, Access Biotechnology, Adjuvant Capital, Andreessen Horowitz, Frazier Healthcare Partners, Brendan Bulik Sullivan, Pureos Bioventures, Sanofi Ventures, Versant Ventures, Vincent Brichard | Announced |
| Sep 1, 2022 | $37M Series A | Daniel Estes, Velosity Capital | 5AM Ventures, Frazier Healthcare Partners | Announced |
| Mar 1, 2022 | $4M Seed | Global Founders Capital | Beenext, Laerdal Million Lives Fund, Partech Ventures, Picus Capital, David Wallerstein, HAM Serunjogi, Odunayo Eweniyi, Olugbenga Agboola, Berrywood Capital, Kepple Africa Ventures, Loftyinc Capital, Rally CAP Ventures, Suya Ventures, Zedcrest | Announced |
Sudo Biosciences has raised $191.0M in total across 4 funding rounds.
Sudo Biosciences's investors include 5AM Ventures, Access Biotechnology, Adjuvant Capital, Andreessen Horowitz, Frazier Healthcare Partners, Brendan Bulik-Sullivan, Pureos Bioventures, Sanofi Ventures, Versant Ventures, Vincent Brichard, Jonathan Behr, Juergen Eckhardt.